Endocrine Abstracts

Background: Von Hippel-Lindau disease (VHL) is an autosomal dominant disease, characterized by haemangioblastomas of the retina and CNS, renal cell carcinomas (RCC) and renal cysts, pheochromocytomas, pancreatic neuroendocrine tumors and cysts, and endolymphatic sac tumors. VHL is associated with a germline mutation of the VHL tumor suppressor gene on the short arm of chromosome 3. The type-1 disease is caused by mutations, leading to severe disruption of protein acti...

Objectives: The frequency of Cushing’s disease (CD), ACTH independent Cushing’s syndrome (CS) and autonomous cortisol secretion (ACS) in patients with obesity is not well known and the results of the studies are heterogeneous. Therefore, in the present study, we aimed to assess the frequency of CD, CS, and ACS among patients with obesity.Methods: In this study, 813 consecutive patients [683 female, mean age 46.47±14.23-year-old, mean BMI 3...

Objective: Despite the high sensitivity of TRAb measured by modern assay methods, some patients with Graves’ disease (GD) may still have normal TRAb levels. Therefore, the purpose of this study was to determine the clinical utility of TRAb measured by a third generation assay method, and to determine it’s relationship with clinical and laboratory parameters in Turkish patients with GD.Methods: In this study, 328 consecutive treatment-naive pati...

Introduction: Although dipeptidyl peptidase-4 (DPP-4) inhibitores are generally safe and are associated with less side effects compared to other oral antidiabetic medications, they could also be associated with some side effects including skin rash. Herein we report the first case of a type 2 diabetes patient who developed a painfull maculopapular rash induced by linagliptin, a widely used DPP-4 inhibitor.Case presentation: A-54-year old female patient w...

Introduction: Obstructive sleep apnea syndrome (OSAS) is a common disorder whose prevalence is linked to an epidemic of obesity. OSAS is caused by recurrent episodes of upper airway obstruction during sleep, leading to reduction or cessation of the airflow. Studies have shown a strong association among OSAS and cardiovascular morbidity and mortality. Therefore, currently we performe overnight polysomnograpy in all patients with obesity in our outpatient clinic. In order to obs...

Introduction: Due to the risk of thyroid storm, achievement of euthyroid state is necessary in patients with thyrotoxicosis undergoing surgery. However, euthyroid state could not be always achieved by antithyroid drugs. Therefore, therapeutic plasmapheresis (TPE) can be used for this purpose.Case 1: A-58-year old male patient was admitted to emergency department with diabetic ketoacidosis (DKA) induced by amiodarone induced thyrotoxicosis (AIT). He had a...